THE UFABET BY LIGAZ DIARIES

DNA ligases seal 5′-PO4 and three′-OH polynucleotide finishes by means of 3 nucleotidyl transfer measures involving ligase-adenylate and DNA-adenylate intermediates. DNA ligases are necessary guardians of genomic integrity, and ligase dysfunction underlies human genetic ailment syndromes. Crystal constructions of DNA ligases bound to nucleotide